Cdx4 regulates the onset of spinal cord neurogenesis
نویسندگان
چکیده
Department of Biology, University of Miami, 1301 Memorial Drive, Coral Gables, Florida, 33146, United States The Miami Project to Cure Paralysis, 1095 NW 14 Terrace R501, Miami, Florida, 33136, United States Department of Neurological Surgery, University of Miami Miller School of Medicine, University of Miami 1095 NW 14 Terrace R501, Miami, Florida, 33136, United States Current Address: Department of Biology, University of Richmond, 28 Westhampton Way B322, Richmond, Virginia, 23173, United States
منابع مشابه
Repression of the hindbrain developmental program by Cdx factors is required for the specification of the vertebrate spinal cord.
The spinal cord is a unique vertebrate feature that originates, together with the hindbrain, from the caudal neural plate. Whereas the hindbrain subdivides into rhombomeres, the spinal cord remains unsegmented. We have identified Cdx transcription factors as key determinants of the spinal cord region in zebrafish. Loss of Cdx1a and Cdx4 functions causes posterior expansion of the hindbrain at t...
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